万宁疟疾防治知识图谱体系英文版（六）

Knowledge Graph System of Hainan Wanning Malaria Control Framework

(Based on 100+ papers from National/Provincial/Wanning Teams, 1988 – 2018)

I. Core Theoretical Layer

1. Transmission Dynamics Theory

　　Key Concepts:

• Upland Exposure Infection Theory (Lin Minghe & Chen Wenjiang, 1999): Mountainous populations exposed to Anopheles dirus during overnight farming activities face 11.3 – 36.8× higher infection risk.
• Mobile Population Importation Model (Zhang Lixin & Li Haiping, 2004): Migrant workers' infection rate is 3 – 5× higher than locals, forming “import – diffusion” chains.

2. Environmental Drivers Theory

　　Key Concepts:

• Altitude – Climate Coupling Effect (Zeng Xiaolu, 2015): Every 100m altitude increase reduces incidence by 12.5%; transmission thresholds at >25°C monthly temp. & >200mm rainfall.
• Land Use Correlation: Rubber plantation expansion reduces mosquito breeding sites.

II. Key Technology Layer

1. Precision Diagnostics

• Blood Smear QC Network (Hu Yuluan & Zhuo Kairen, 2003): Standardized microscopy protocols raising accuracy from 60% to 90%.
• Co – infection PCR Detection (Lin Minghe & Wu Kaichen, 1999): Multiplex PCR for P. vivax/falciparum co – detection (sensitivity + 30%).

2. Drug Interventions

• Piperaquine – Primaquine 4 – Day Regimen (Lin Minghe et al., 1996): Mass drug administration achieving >85% coverage, relapse reduction 72%.
• Artemisinin Combination Therapy (ACT) Optimization:“Artemisinin + Piperaquine” and “Dihydroartemisinin + Naphthoquine” (Nanqiao Township Health Center, 2008 – 2012): 100% cure rate for drug – resistant P. falciparum.

3. Vector Control

• LLINs with Permethrin (1994): Treated bed nets reducing vector density by 95%.
• Breeding Site Eco – Management: Vegetation clearance to disrupt mosquito habitats.

III. Control Model Layer

1. “Three – Priorities” Targeted Control

• Priority Zones: Mountain farming areas/border villages (4.2× higher incidence).
• Priority Populations: Upland farmers, migrants, ethnic minorities.
• Priority Actions: Case reporting <24h, focus response <72h.

2. Health Education – Behavioral Intervention

• Community participatory education via Li ethnic festivals (“March 3”).
• Subsidized bed nets increasing usage from 28.6% to 72.6%.

3. Cross – Border Joint Prevention

• Real – time case sharing system (China – Myanmar border).

IV. Support System Layer

1. Data – Driven Decision Platform

• Remote Sensing – GIS Early Warning (Su Yongqiang, 2003): Integrates climate/land use/mobility data (>80% prediction accuracy).
• Risk Assessment Model (Mo Xiaotong, 2021): R0 – M index for importation – related resurgence risk.

2. Multi – Level Governance

• Province – City – Village Network: Provincial experts → City CDC → Village microscopy stations.
• Cross – Sector Collaboration: Health/agriculture/forestry joint breeding site management.

3. Sustainability Mechanisms

• Policy: Hainan Malaria Elimination Action Plan (2010 – 2020).
• Funding: 15.6% average annual growth for mountain – area programs (2000 – 2018).
• Workforce: “Dual – qualified” health workers (clinical + epidemiological skills).

Knowledge Graph Visualization

Key Relationships:

• Environmental Drivers → GIS Platform (data foundation)
• ACT Optimization → Cross – Border Coordination (drug resistance breakthrough)
• Mobile Population Model → “Three – Priorities” Targeting (high – risk group focus)

项目负责人：许晓艺 陈宏任

广东职业教育信息化研究会 2025年12月8日